Professor Bruce Whitelaw

The Roslin Institute

Research Interests

My group investigates the molecular events that accompany changes in the expression status of genes in mammals. We aim to develop and exploit gene transfer technology to investigate differentiation in mammals and exemplify the use of this technology through the generation of animal models of human disease, novel in vivo screening resources, and animals more able to combat infectious disease.

This work will advance our understanding of how cellular signals integrate to allow tissues to work normally in the whole animal, while identifying routes to intervene when normal development is perturbed through disease. We aim to exploit this knowledge to develop innovative biotechnological solutions to combat infectious disease in animals, evaluate new treatments of human disease through transgenic animal models, and establish efficient protein production systems in animals.

Selected Publications

  • B. Whitelaw. 2011. An introduction to non-mouse models. More»
  • R. Wall, G. Laible, E. Mega, G. Seiel, C. B. A. Whitelaw. 2009. Animal Productivity and Genetic Diversity: Cloned and Transgenic Animals. Animal Agriculture's Future through Biotechnology, Part 8. More»
  • A. J. Clark, Alan Archibald, M McClenaghan, J. P. Simons, Bruce Whitelaw, Ian Wilmut. 1990. The germline manipulation of livestock: progress during the past five years.. Proc NZ Soc Animal Prod Vol: 50 Pages: 167-179. More»
  • Clare Pridans, Gemma Davis, Kristin Sauter, Zofia Lisowski, Yolanda Corripio-Miyar, Anna Raper, Lucas Lefevre, Rachel Young, Mary E. McCulloch, Simon Lillico, Elspeth Milne, Christopher Whitelaw, David Hume. 2016. A Csf1r-EGFP transgene provides a novel marker for monocyte subsets in sheep. Journal of Immunology Vol: 197 Pages: 2297-2305. More»
  • C B Whitelaw. 1996. Hormonal influences on beta-lactoglobulin transgene expression inferred from chromatin structure. Biochemical and Biophysical Research Communications Vol: 224 Pages: 121-5. More»
  • M. Mcclenaghan, Alan Archibald, S. Harris, J.p. Simons, Bruce Whitelaw, I. Wilmut, A.j. Clark. 1991. Production of human α 1 ‐antitrypsin in the milk of transgenic sheep and mice: Targeting expression of CDNA sequences to the mammary gland. Animal biotechnology Vol: 2 Pages: 161-176. More»
  • Bruce Whitelaw, Alan Archibald, S. Harris, M McClenaghan, J. P. Simons, C J Watson, Ian Wilmut, A. J. Clark. 1990. Expression of b-lactoglobulin and hybrid transgenes in the mammary gland.. More»
  • Christine Tait-burkard, Andrea Doeschl-wilson, Mike J. Mcgrew, Alan L. Archibald, Helen M. Sang, Ross D. Houston, C. Bruce Whitelaw, Mick Watson. 2018. Livestock 2.0 – genome editing for fitter, healthier, and more productive farmed animals. Genome Biology Vol: 19. More»
  • C Scudamore, Elizabeth J Soilleux, Natasha A Karp, Ken Smith, Richard Poulsom, Charles Herrington, Michael Day, Cory Brayton, Brad Bolon, Christopher Whitelaw, Eric White, Jeffrey Everitt, Mark Arends. 2016. Recommendations for Minimum Information for Publication of Experimental Pathology Data: MINPEPA Guidelines. The Journal of Pathology Vol: 238 Pages: 359-367. More»
  • Akos Gerencsér, Endre Barta, Simon Boa, Petros Kastanis, Zsuzsanna Bösze, C Bruce A Whitelaw. 2002. Comparative analysis on the structural features of the 5' flanking region of kappa-casein genes from six different species. Genetics Selection Evolution Vol: 34 Pages: 117-28. More»
  • Bruce Whitelaw. 1992. Transgenic animals as bioreactors. AgBiotech News and Information Vol: 4 Pages: 371N-372N. More»
  • Janez Jenko, Gregor Gorjanc, Matthew A Cleveland, Rajeev K Varshney, C Bruce A Whitelaw, John A Woolliams, John M Hickey. 2015. Erratum to: Potential of promotion of alleles by genome editing to improve quantitative traits in livestock breeding programs. Genetics Selection Evolution Vol: 47 Pages: 69. More»
  • B Whitelaw. 2001. Transgenic animal welfare. Transgenic Research Vol: 10 Pages: 375. More»
  • H.M. Hodgkiss-Geere, D.J. Argyle, B.M. Corcoran, B. Whitelaw, E. Milne, D. Bennett, S.A. Argyle. 2011. Cardiac Specific Gene Expression Changes in Long Term Culture of Murine Mesenchymal Stem Cells. International Journal of Stem Cells Vol: 4 Pages: 143-148. More»
  • Ann Bruce, David Castle, Corinna Gibbs, Joyce Tait, Bruce Whitelaw. 2013. Novel GM Animal Technologies and their Governance. Transgenic Research Vol: 22 Pages: 681-695. More»
  • D. A. Hume, C. B. A. Whitelaw, A. L. Archibald. 2012. Genotype Selection and Modification and the Future of Livestock Production. More»
  • G Donofrio, E Bignetti, A J Clark, C B Whitelaw. 1996. Comparable processing of beta-lactoglobulin pre-mRNA in cell culture and transgenic mouse models. Molecular & general genetics Vol: 252 Pages: 465-9. More»
  • Paolo Gottardo, Gregor Gorjanc, Mara Battagin, Robert Gaynor, Janez Jenko, Roger Ros Freixedes, Christopher Whitelaw, Alan Mileham, William O. Herring, John Hickey. 2019. A strategy to exploit surrogate sire technology in livestock breeding programs. G3 Vol: 9 Pages: 203-215. More»
  • Ian Wilmut, D.N. Wells, J McWhir, M. L. Hooper, W. A. Ritchie, Bruce Whitelaw, Alan Archibald, M McClenaghan, J. P. Simons, A. J. Clark. 1991. Advances in animal biotechnology: Embryo micromanipulation and gene transfer. More»
  • Zuyong He, Christopher Proudfoot, Christopher Whitelaw, Simon Lillico. 2016. Comparison of CRISPR/Cas9 and TALENs on editing an integrated EGFP gene in the genome of HEK293FT cells. SpringerPlus Vol: 5. More»
  • R. C. Huber, L. Remuge, A. Carlisle, S. Lillico, P. Sandoe, D. B. Sorensen, Bruce Whitelaw, I. A. S. Olsson. 2012. Welfare assessment in transgenic pigs expressing green fluorescent protein (GFP). Transgenic Research Vol: 21 Pages: 773-784. More»
  • Reinhard C. Huber, Andreas F. Kolb, Simon Lillico, Ailsa Carlisle, Peter Sandoe, Dorte B. Sorensen, Liliana Remuge, Bruce C. A. Whitelaw, Anna I. S. Olsson. 2013. Behaviour of postnatally growth-impaired mice during malnutrition and after partial weight recovery. Nutritional neuroscience Vol: 16 Pages: 125-134. More»
  • Luise A Seeker, Joanna Warner, Androniki Psifidi, Rachael Wilbourn, Sarah Underwood, Jennifer Fairlie, Rebecca Holland, Hannah Froy, Eliane Salvo-Chirnside, Ainsley Bagnall, Christopher Whitelaw, Mike Coffey, Daniel Nussey, Georgios Banos. 2018. Bovine telomere dynamics and the association between telomere length and productive lifespan. Scientific Reports Vol: 8. More»
  • Florian Wölbing, J. Marschall, C. Lassnig, U. Schulte, A. Kolb, Bruce Whitelaw, M. Mueller, T. Biedermann, M. Huber. 2012. CD13 is a negative regulator of Fc epsilon RI dependent mast cell activation in vitro and anaphylaxis in vivo. More»
  • Susan Tamowski, Jinping Luo, Benoît Kanzler, Bruce Whitelaw, Martina Crispo, Lynn Doglio, Boris Jerchow, Jan Parker-Thornburg. 2016. TT2016 meeting report on the 13th Transgenic Technology meeting in Prague, Czech Republic. Transgenic Research. More»
  • James Glover, M. McGrew, H. Sang, B. Whitelaw, L. Taylor. 2011. Investigating the role of PRDM14 in avian germ cell development using an inducible transposon system. More»
  • D.j. Flint, E. Tonner, C.h. Knight, Bruce Whitelaw, J. Webster, M. Barber, G. Allan. 2001. Control of mammary involution by insulin-like growth factor binding proteins: role of prolactin. Livestock Production Science Vol: 70 Pages: 115-120. More»
  • C H Streuli, G M Edwards, M Delcommenne, C B Whitelaw, T G Burdon, C Schindler, C J Watson. 1995. Stat5 as a target for regulation by extracellular matrix. Journal of Biological Chemistry Vol: 270 Pages: 21639-44. More»
  • A. J. Clark, Alan Archibald, M McClenaghan, J. P. Simons, Bruce Whitelaw, Ian Wilmut. 1991. Targeting gene expression to the mammary gland. More»
  • Bruce Whitelaw. 1995. Pharmaceuticals from transgenic sheep. Biological Sciences Review Vol: 7 Pages: 25-27. More»
  • Janez Jenko, Gregor Gorjanc, Gabor Meszaros, Bruce Whitelaw, John Woolliams, Matthew A. Cleveland, John Hickey. 2014. Use of Genome Editing in Animal Breeding P rograms. More»
  • Bruce Whitelaw, Alan Archibald, F E Hitchin, M McClenaghan, J. P. Simons, C J Watson, Ian Wilmut, A. J. Clark. 1990. The molecular manipulation of milk. More»
  • J Suk, A Bruce, R Gertz, C Warkup, C B A Whitelaw, A Braun, C Oram, E Rodríguez-cerezo, I Papatryfon. 2007. Dolly for dinner? Assessing commercial and regulatory trends in cloned livestock. Nature Biotechnology Vol: 25 Pages: 47-53. More»
  • A F Kolb, L Pewe, J Webster, S Perlman, C B Whitelaw, S G Siddell. 2001. Virus-neutralizing monoclonal antibody expressed in milk of transgenic mice provides full protection against virus-induced encephalitis. Journal of Virology Vol: 75 Pages: 2803-9. More»
  • Douglas Strathdee, C Bruce A Whitelaw. 2013. TT2013 meeting report: the Transgenic Technology meeting visits Asia for the first time. Transgenic Research Vol: 22 Pages: 667-71. More»
  • R. Huber, D.B. Sorensen, P. Sandoe, B. Whitelaw, A.S. Olssen. 2009. Of mice and pigs - tackling the lack of welfare assessment (protocols) in transgenic farms animals. More»
  • J Webster, R M Wallace, A J Clark, C B Whitelaw. 1995. Tissue-specific, temporally regulated expression mediated by the proximal ovine beta-lactoglobulin promoter in transgenic mice. Cellular & molecular biology research Vol: 41 Pages: 11-5. More»
  • A. Menchaca, I. Anegon, Bruce Whitelaw, H. Baldassarre, M. Crispo. 2016. New insights and current tools for genetically engineered (GE) sheep and goats. Theriogenology Vol: 86 Pages: 160-169. More»
  • H. Hodgkiss-Geere, D. Argyle, B. Corcoran, E. Milne, Bruce Whitelaw, D. Bennett, S. Argyle. 2010. Characterisation and cardiac directed differentiation of canine adult stem cells. More»
  • Christopher Whitelaw, Simon Lillico. 2017. GENETICALLY-EDITED SWINE. More»
  • L.Y. Pang, M. Scott, R.L. Hayward, H. Mohammed, C.B. Whitelaw, G.C. Smith, T.R. Hupp. 2011. p21 (WAF1) is component of a positive feedback loop that maintains the p53 transcriptional program. Cell Cycle Vol: 10 Pages: 932-950. More»
  • C B Whitelaw. 1995. Regulation of ovine beta-lactoglobulin gene expression during the first stage of lactogenesis. Biochemical and Biophysical Research Communications Vol: 209 Pages: 1089-93. More»
  • Bruce Whitelaw, Alan Archibald, Stephen Harris, Maggie McClenaghan, Anthea Springbett, Paul J Simons, Roberta Wallace, John A. Clark. 1990. Frequency of germline mosaicism in founder transgenic mice. Mouse Genome Vol: 88 Pages: 114. More»
  • Marieta Gencheva, Simon Boa, Ross Fraser, Martin Simmen, Bruce Whitelaw, James Allan. 2006. In Vitro and in Vivo nucleosome positioning on the ovine beta-lactoglobulin gene are related. Journal of Molecular Biology Vol: 361 Pages: 216. More»
  • Thomas Tzelos, Jacqueline B Matthews, Amy H Buck, Fabio Simbari, David Frew, Neil F Inglis, Kevin McLean, Alasdair J Nisbet, C Bruce A Whitelaw, David P Knox, Tom N McNeilly. 2016. A preliminary proteomic characterisation of extracellular vesicles released by the ovine parasitic nematode, Teladorsagia circumcincta. Veterinary Parasitology Vol: 221 Pages: 84-92. More»
  • Janez Jenko, Gregor Gorjanc, Matthew A Cleveland, Rajeev K Varshney, C Bruce A Whitelaw, John A Woolliams, John M Hickey. 2015. Potential of promotion of alleles by genome editing to improve quantitative traits in livestock breeding programs. Genetics Selection Evolution Vol: 47. More»
  • P Christou, B Whitelaw. 2000. Frontiers in transgenic research. Transgenic Research Vol: 9 Pages: 241-2. More»
  • Dequan Xu, Simon G. Lillico, Mark W. Barnett, Christopher B. A. Whitelaw, Alan L. Archibald, Tahar Ait-Ali. 2012. USP18 restricts PRRSV growth through alteration of nuclear translocation of NF-κB p65 and p50 in MARC-145 cells. Virus Research Vol: 169 Pages: 264-267. More»
  • Jon M. Oatley, Christopher Whitelaw, Simon Lillico, Bhanu Telugu. 2015. Nanos knock-out that ablates germline cells.. More»
  • James D. Murray, Bruce Whitelaw, Lluís Montoliu. 2007. Meeting Report: UC Davis Transgenic Animal Research Conference VI: Granlibakken Conference Center, Tahoe City, California, August 12–16, 2007. Transgenic Research Vol: 16 Pages: 835-837. More»
  • Tahar Ait-Ali, Simon Lillico, Alan Archibald, Christopher Whitelaw. 2014. Domain 5 of cd163 for use in antiviral compositions against prrs, and transgenic animals. More»
  • J. L. Vilotte, E. Chanat, F. Le Provost , Bruce Whitelaw, A. Kolb, D. B. Shennan. 2013. Genetics and Biosynthesis of Milk Proteins. More»
  • C B Whitelaw. 2000. Nucleosome organisation of the beta-lactoglobulin gene. Transcription complex formation. Advances in Experimental Medicine and Biology Vol: 480 Pages: 147-53. More»
  • Amandine Breton, Ruchi Sharma, Andrea Catalina Diaz, Alea Gillian Parham, Audrey Graham, Claire Neil, Christopher Bruce Whitelaw, Elspeth Milne, Francesc Xavier Donadeu. 2013. Derivation and Characterization of Induced Pluripotent Stem Cells from Equine Fibroblasts. Stem Cells and Development Vol: 22 Pages: 611-621. More»
  • Andreas F Kolb, Reinhard C Huber, Simon G Lillico, Ailsa Carlisle, Claire J Robinson, Claire Neil, Linda Petrie, Dorte B Sorensen, I Anna S Olsson, C Bruce A Whitelaw. 2011. Milk Lacking α-Casein Leads to Permanent Reduction in Body Size in Mice. PLoS ONE Vol: 6. More»
  • E Farini, C B Whitelaw. 1995. Ectopic expression of beta-lactoglobulin transgenes. Molecular & general genetics Vol: 246 Pages: 734-8. More»
  • T. Tzelos, J. B. Matthews, B. Whitelaw, D. P. Knox. 2015. Marker genes for activation of the RNA interference (RNAi) pathway in the free-living nematode Caenorhabditis elegans and RNAi development in the ovine nematode Teladorsagia circumcincta. Journal of helminthology Vol: 89 Pages: 208-216. More»
  • William A Ritchie, Claire Neil, Tim King, C Bruce A Whitelaw. 2007. Transgenic embryos and mice produced from low titre lentiviral vectors. Transgenic Research Vol: 16 Pages: 661-4. More»
  • C. B. Whitelaw. 2016. Gene targeting, genome editing: from Dolly to editors. Transgenic Research Vol: 25 Pages: 102-103. More»
  • H. M. Hodgkiss-Geere, D. J. Argyle, B. M. Corcoran, B. Whitelaw, E. Milne, D. Bennett, S. A. Argyle. 2012. Characterisation and differentiation potential of bone marrow derived canine mesenchymal stem cells. Veterinary Journal Vol: 194 Pages: 361-368. More»
  • A J Clark, P Bissinger, D W Bullock, S Damak, R Wallace, C B Whitelaw, F Yull. 1994. Chromosomal position effects and the modulation of transgene expression. Reproduction, Fertility and Development Vol: 6 Pages: 589-98. More»
  • Lisa Pang, Emma Gattenby, Ayako Kamido, Bruce Whitelaw, Ted Hupp, David Argyle. 2014. Global gene expression analysis of canine osteosarcoma stem cells reveals a novel role for COX-2 in tumour initiation. PLoS ONE Vol: 9. More»
  • D J Flint, M Boutinaud, C B A Whitelaw, G J Allan, A F Kolb. 2006. Prolactin inhibits cell loss and decreases matrix metalloproteinase expression in the involuting mouse mammary gland but fails to prevent cell loss in the mammary glands of mice expressing IGFBP-5 as a mammary transgene. Journal of molecular endocrinology Vol: 36 Pages: 435-48. More»
  • Christine Burkard, Tanja Opriessnig, Alan J Mileham, Tomasz Stadejek, Tahar Ait-Ali, Simon G Lillico, C Bruce A Whitelaw, Alan L Archibald. 2018. Pigs lacking the scavenger receptor cysteine-rich domain 5 of CD163 are resistant to PRRSV-1 infection. Journal of Virology. More»
  • J. Raper, R. Zipkin, J. Verdi, S. Suhr, J. Cibelli, C. Schoenherr, A. Economides, D. Frendewey, V. Lai, D. Valenzuela, C. Proudfoot, S. Lillico, B. Ritchie, B. Whitelaw, A. Archibald, M. Y. Yu, S. Kemp. 2016. Introducing genetic resistance for trypanosomiasis into sheep and cattle. Transgenic Research Vol: 25 Pages: 102. More»
  • J. L. Vilotte, Bruce Whitelaw, M. Ollivier-Bousquet, D. B. Shennan. 2003. Biosynthesis of Milk Proteins. More»
  • Z. Bosze, M. Baranyi, C. B. A. Whitelaw. 2008. Producing recombinant human milk proteins in the milk of livestock species. More»
  • A. Capocefalo, V. Franceschi, C. B. A. Whitelaw, D. B. Vasey, S. G. Lillico, S. Cavirani, G. Donofrio. 2009. p21(Waf1/Cip1) as a molecular sensor for BoHV-4 replication. Journal of Virological Methods Vol: 161 Pages: 308-311. More»
  • Zuyong He, Christopher Proudfoot, Alan J. Mileham, David G. Mclaren, C. Bruce A Whitelaw, Simon G. Lillico. 2015. Highly efficient targeted chromosome deletions using CRISPR/Cas9. Biotechnol Bioeng Vol: 112 Pages: 1060-1064. More»
  • E Tonner, G Allan, L Shkreta, J Webster, C B Whitelaw, D J Flint. 2000. Insulin-like growth factor binding protein-5 (IGFBP-5) potentially regulates programmed cell death and plasminogen activation in the mammary gland. Advances in Experimental Medicine and Biology Vol: 480 Pages: 45-53. More»
  • A. Kaucher, K. E. Park, M. Oatley, A. Powell, D. M. Donovan, L. A. Blomberg, S. Lillico, B. Whitelaw, A. Mileham, B. Telugu, J. Oatley. 2016. Production of germline ablated male pigs via Crispr/Cas editing of the NANOS2 gene. Transgenic Research Vol: 25 Pages: 209-210. More»
  • Rachel Huddart, Chris Proudfoot, Daniel Carlson, Charles Long, Jane Prior, Tim King, Simon Lillico, Alan Mileham, David McLaren, Bruce Whitelaw, Scott Fahrenkrug. 2014. Editing myostatin in livestock animals. Transgenic Research Vol: 23 Pages: 867-867. More»
  • L Y Pang, Thalia Blacking, R W Else, A Sherman, H M Sang, B A Whitelaw, T R Hupp, D J Argyle. 2013. Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway. Veterinary Journal Vol: 196 Pages: 414-423. More»
  • Rachel Young, John D. Hayes, Ken Brown, C. Roland Wolf, C. Bruce A. Whitelaw. 2010. Peroxiredoxin Gene Expression Signatures in Liver Reflect Toxic Insult. Assay and Drug Development Technologies Vol: 8 Pages: 512-517. More»
  • A J Clark, A L Archibald, M McClenaghan, J P Simons, R Wallace, C B Whitelaw. 1993. Enhancing the efficiency of transgene expression. Philosophical Transactions of the Royal Society B: Biological Sciences Vol: 339 Pages: 225-32. More»
  • Lluis Montoliu, C Bruce A Whitelaw. 2018. Unexpected mutations were expected and unrelated to CRISPR-Cas9 activity. Transgenic Research Vol: 27 Pages: 315-319. More»
  • L. Nelson, S. Anderson, A. L. Archibald, S. Rhind, Z. H. Lu, A. Condie, Neil Macintyre, J. Thompson, R. Nenutil, B. Vojtesek, C. B. Whitelaw, T. J. Little, T. Hupp. 2008. An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses. Cell Stress and Chaperones Vol: 13 Pages: 375-385. More»
  • Bruce Whitelaw. 2008. RNA-based biotechnologies: potential future impact on animal health.. OIE Bulletin Vol: 2 Pages: 15-19. More»
  • R M James, C Neil, J Webster, S Roos, A J Clark, C B Whitelaw. 2000. Multiple copies of beta-lactoglobulin promoter do not function as LCR. Biochemical and Biophysical Research Communications Vol: 272 Pages: 284-9. More»
  • Andreas F Kolb, C Bruce A Whitelaw. 2006. A virus-neutralising antibody is not cytotoxic in vitro. Molecular Immunology Vol: 43 Pages: 677-89. More»
  • B. Whitelaw. 2013. Viral and nonviral vectors. Reproduction, Fertility and Development Vol: 25 Pages: 317. More»
  • A.J. Springbett, Tom Burdon, F.E. Yull, Bruce Whitelaw. 1993. Comment on mosaic nature of G0 transgenic mice.. Mouse Genome Vol: 91 Pages: 113. More»
  • Ramona N Pena, C Bruce A Whitelaw. 2005. Duplication of Stat5-binding sites within the beta-lactoglobulin promoter compromises transcription in vivo. Biochimie Vol: 87 Pages: 523-8. More»
  • D. B. Vasey, C. R. Wolf, T. MacArtney, K. Brown, C. B. Whitelaw. 2008. p21-LacZ reporter mice reflect p53-dependent toxic insult. Toxicology and Applied Pharmacology Vol: 227 Pages: 440-450. More»
  • C B Whitelaw, S Harris, M McClenaghan, J P Simons, A J Clark. 1992. Position-independent expression of the ovine beta-lactoglobulin gene in transgenic mice. Biochemical Journal Vol: 286 ( Pt 1) Pages: 31-9. More»
  • Reinhard Huber, Anna Olsson, Dorte Sorensen, Simon Lillico, Peter Sandoe, Bruce Whitelaw. 2010. Developing welfare protocols for transgenic large animals. Transgenic Research Vol: 19 Pages: 138-138. More»
  • Christopher Proudfoot, Daniel F Carlson, Rachel Huddart, Charles R Long, Jane H Pryor, Tim J King, Simon G Lillico, Alan J Mileham, David G McLaren, C Bruce A Whitelaw, Scott C Fahrenkrug. 2015. Genome edited sheep and cattle. Transgenic Research Vol: 24 Pages: 147-153. More»
  • M. K. Ballantyne, S. G. Lillico, A. J. Mileham, C. B. Whitelaw. 2016. Engineering resilience to African swine fever. Transgenic Research Vol: 25 Pages: 101-102. More»
  • Luise Seeker, Joanna Warner, Androniki Psifidi, Rachael Wilbourn, Sarah Underwood, Jennifer Fairlie, Rebecca Holland, Ainsley Bagnall, Christopher Whitelaw, Mike Coffey, Daniel Nussey, Georgios Banos. 2018. Longitudinal changes in telomere length and associated genetic parameters in dairy cattle analysed using random regression models. PLoS ONE Vol: 13. More»
  • G Donofrio, S Cavirani, B Whitelaw, C F Flammini, F Scatozza. 2000. Transfection of bovine cell culture with bovine herpesvirus 4 DNA obtained by cell nuclear extraction. The new microbiologica Vol: 23 Pages: 129-35. More»
  • John Hickey, Christopher Whitelaw, Gregor Gorjanc. 2016. Promotion of alleles by genome editing in livestock breeding programmes. Journal of Animal Breeding and Genetics Vol: 133 Pages: 83-84. More»
  • C B Whitelaw, A J Springbett, J Webster, J Clark. 1993. The majority of G0 transgenic mice are derived from mosaic embryos. Transgenic Research Vol: 2 Pages: 29-32. More»
  • D J Flint, M Boutinaud, E Tonner, C J Wilde, W Hurley, P A Accorsi, A F Kolb, C B A Whitelaw, J Beattie, G J Allan. 2005. Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland. Domestic Animal Endocrinology Vol: 29 Pages: 274-82. More»
  • Gus R. McFarlane, C. Bruce A. Whitelaw, Simon G. Lillico. 2018. CRISPR-Based Gene Drives for Pest Control. Trends in biotechnology Vol: 36 Pages: 130-133. More»
  • Bruce Whitelaw. 2012. Transgenic Livestock for Food Production, An Introduction to.. More»
  • C B Whitelaw, S Grolli, P Accornero, G Donofrio, E Farini, J Webster. 2000. Matrix attachment region regulates basal beta-lactoglobulin transgene expression. Gene Vol: 244 Pages: 73-80. More»
  • S. C. Fahrenkrug, W. F. Tan, S. G. Lillico, D. Stverakova, C. Proudfoot, G. Williamson, C. R. Long, B. A. Whitelaw, D. F. Carlson. 2013. Gene inactivation and nonmeiotic allele introgression in livestock species using talens. Reproduction, Fertility and Development Vol: 25 Pages: 318. More»
  • Caode Jiang, Yongsheng Yang, Chenchen Huang, Bruce Whitelaw. 2014. Promoter characterization and functional association with placenta of porcine MAGEL2. Gene Vol: 547 Pages: 63-69. More»
  • Roy Forster, Philippe Ancian, Merete Fredholm, Henner Simianer, Bruce Whitelaw, RETHINK Project. 2010. The minipig as a platform for new technologies in toxicology. Journal of Pharmacological and Toxicological Methods Vol: 62 Pages: 227-235. More»
  • R. Manickam, R. N. Pena, C. B. Whitelaw. 2008. Mammary gland differentiation inversely correlates with GDF-8 expression. Molecular Reproduction and Development Vol: 75 Pages: 1783-1788. More»
  • J. S. Zotz, F. Wo lbing, C. Lassnig, M. Kauffmann, U. Schulte, A. Kolb, B. Whitelaw, M. Mu ller, T. Biedermann, M. Huber. 2016. CD13/aminopeptidase N is a negative regulator of mast cell activation. The FASEB Journal Vol: 30 Pages: 2225-2235. More»
  • Clare Pridans, Simon Lillico, Bruce Whitelaw, David A Hume. 2014. Lentiviral vectors containing mouse Csf1r control elements direct macrophage-restricted expression in multiple species of birds and mammals. Molecular Therapy — Methods & Clinical Development Vol: 1. More»
  • Bhuvaneish Thangaraj Selvaraj, Matthew Livesey, Jenna Gregory, Amit Chouhan, Emma Perkins, Owen Dando, Simon Lillico, Navneet Vasistha, Dario Magnani, David Story, Peter Kind, Timothy Aitman, Christopher Whitelaw, Ian Wilmut, Colin Smith, Giles Hardingham, David Wyllie, Siddharthan Chandran and 14 others. 2018. C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity. Nature Communications Vol: 9 Pages: 347. More»
  • C B A Whitelaw, H M Sang. 2005. Disease-resistant genetically modified animals. Revue scientifique et technique-Office international des epizooties Vol: 24 Pages: 275-83. More»
  • Fabienne Le Provost, Simon Lillico, Bruno Passet, Rachel Young, Bruce Whitelaw, Jean-Luc Vilotte. 2010. Zinc finger nuclease technology heralds a new era in mammalian transgenesis. Trends in biotechnology Vol: 28 Pages: 134-141. More»
  • J. M. Rowe, C. Welsh, R. N. Pena, C. R. Wolf, K. Brown, C. B. Whitelaw. 2008. Illuminating Role of CYP1A1 in Skin Function. Journal of Investigative Dermatology Vol: 128 Pages: 1866-1868. More»
  • Bruce Whitelaw. 2001. Pharmaceutical proteins in milk from transgenic animals.. More»
  • J C Lang, N M Wilkie, A M Clark, A Chudleigh, S Talbot, B Whitelaw, Margaret Frame. 1991. Regulatory domains within the P0 promoter of human c-myc. Oncogene Vol: 6 Pages: 2067-75. More»
  • C B Whitelaw, E Farini, J Webster. 1999. The changing role of cell culture in the generation of transgenic livestock. Cytotechnology Vol: 31 Pages: 3-8. More»
  • S. C. Fahrenkrug, W. Tan, S. G. Lillico, D. Stverakova, C. Proudfoot, G. Williamson, C. R. Long, C. B. A. Whitelaw, D. F. Carlson. 2013. Nonmeiotic introgression of quantitative trait nucleotides and correction of congenital mutations in livestock with transcription activator-like effector nucleases. Reproduction, Fertility and Development Vol: 25 Pages: 316. More»
  • Jia Tong, Simon G Lillico, Ming Jun Bi, Tong Qing, Xiao Fang Liu, Yuanyuan Wang, Min Zheng, Meili Wang, Yun Ping Dai, C Bruce A Whitelaw, Ning Li. 2011. Tissue-specific and expression of porcine growth hormone gene in BAC transgenic mice. Transgenic Research Vol: 20 Pages: 933-8. More»
  • William A Ritchie, Jane E Taylor, John O Gardner, Ian Wilmut, Ailsa Carlisle, Claire Neil, Tim King, C Bruce A Whitelaw. 2005. Live lambs born from zona-pellucida denuded embryos. Cloning and Stem Cells Vol: 7 Pages: 178-82. More»
  • Bruce Whitelaw, A J Clark. 1999. Optimisation of transgene expresssion in the mammary gland.. More»
  • C. Kostic, N. Grandchamp, T. King, S. Crippa, S. Philippe, S. Lillico, C. Sarkis, J. Mallet, Y. Arsenijevic, B. Whitelaw. 2012. Lentiviral-directed transgenesis in swine is an efficient tool to study human dominant genetic diseases. Human Gene Therapy Vol: 23 Pages: A147-A147. More»
  • Ruchi Sharma, Matthew R Livesey, David Ja Wyllie, Christopher Proudfoot, Bruce Whitelaw, David C Hay, Xavier Donadeu. 2014. Generation of functional neurons from feeder-free, keratinocyte-derived equine induced pluripotent stem cells. Stem Cells and Development Vol: 23 Pages: 1524-1534. More»
  • B Whitelaw. 1999. Toward designer milk. Nature Biotechnology Vol: 17 Pages: 135-6. More»
  • Simon Lillico, Christopher Proudfoot, Timothy King, Wenfang Tan, Lei Zhang, Rachel Mardjuki, David E. Paschon, Edward J Rebar, Fyodor D Urnov, Alan J Mileham, David G McLaren, Christopher Whitelaw. 2016. Mammalian interspecies substitution of immune modulatory alleles by genome editing. Scientific Reports Vol: 6. More»
  • Emily Clark, Stephen Bush, Mary McCulloch, Iseabail Farquhar, Rachel Young, Lucas Lefevre, Clare Pridans, Hiu-gwen Tsang, Chunlei Wu, Cyrus Afrasiabi, Michael Watson, Christopher Whitelaw, Tom Freeman, Kim Summers, Alan Archibald, David Hume. 2017. A high resolution atlas of gene expression in the domestic sheep (Ovis aries). PLoS Genetics Vol: 13. More»
  • D. Strathdee, C. B. A. Whitelaw, A. J. Clark. 2008. Distal transgene insertion affects CpG island maintenance during differentiation. Journal of Biological Chemistry Vol: 283 Pages: 11509-11515. More»
  • Douglas B. Vasey, C. Roland Wolf, Ken Brown, C. Bruce A. Whitelaw. 2011. Spatial p21 expression profile in the mid-term mouse embryo. Transgenic Research Vol: 20 Pages: 23-28. More»
  • Lluis Montoliu, C. Bruce A. Whitelaw. 2011. Using standard nomenclature to adequately name transgenes, knockout gene alleles and any mutation associated to a genetically modified mouse strain. Transgenic Research Vol: 20 Pages: 435-440. More»
  • Bruce Whitelaw. 1993. Chromatin structure of ß-lactoglobulin transgenes. More»
  • Bruce Whitelaw, John Webster. 1998. Chromatin heterogeneity within multicopy transgene arrays. Transgenic Research Vol: 7 Pages: 401-402. More»
  • Emily L. Clark, Iseabail L. Farquhar, Mary B. McCulloch, Stephen J. Bush, C. Bruce Whitelaw, Michael Watson, Kim M. Summers, Alan L. Archibald, David A. Hume. 2016. The sheep gene expression atlas project. More»
  • C Bruce A Whitelaw. 2004. Transgenic livestock made easy. Trends in biotechnology Vol: 22 Pages: 157-9; discussion 159-60. More»
  • Lydia Teboul, Yann Hérault, Cynthia Smith, Bruce Whitelaw. 2017. Introduction to Mammalian Genome Special Issue: Genome editing. Mammalian Genome Vol: 28 Pages: 235-236. More»
  • A J Clark, S Ali, A L Archibald, H Bessos, P Brown, S Harris, M McClenaghan, C Prowse, J P Simons, C B Whitelaw. 1989. The molecular manipulation of milk composition. Mammalian Genome Vol: 31 Pages: 950-5. More»
  • Bruce Whitelaw. 2014. After three decades of GE animals: what will the 4th bring?. Transgenic Research Vol: 23 Pages: 200-201. More»
  • Andreas F Kolb, David Sorrell, Caroline Lassnig, Simon Lillico, Ailsa Carlisle, Claire Neil, Claire Robinson, Mathias Müller, C Bruce A Whitelaw. 2012. Mammary gland development is delayed in mice deficient for aminopeptidase N. Transgenic Research Vol: 22 Pages: 425-434. More»
  • C. B. A. Whitelaw, Simon Lillico, T. King. 2008. Production of transgenic farm animals by viral vector mediated gene transfer. Reproduction in Domestic Animals Vol: 43 Pages: 355-358. More»
  • Emily Clark, Stephen Bush, Kim Summers, David Hume, Christopher Whitelaw, Michael Watson, Iseabail Farquhar, Alan Archibald. 2017. Functional Annotation of the Sheep (Ovis aries) Genome. More»
  • J C Lang, B Whitelaw, S Talbot, N M Wilkie. 1988. Transcriptional regulation of the human c-myc gene. The British journal of cancer. Supplement Vol: 9 Pages: 62-6. More»
  • M. Ballantyne, S. Lillico, C. Proudfoot, D. Carlson, D. McLaren, A. Mileham, S. Fahrenkrug, B. Whitelaw. 2014. TALEN-mediated engineering of the porcine genome. Transgenic Research Vol: 23 Pages: 202-202. More»
  • R N Pena, J M Folch, A Sánchez, C B Whitelaw. 1998. Chromatin structures of goat and sheep beta-lactoglobulin gene differ. Biochemical and Biophysical Research Communications Vol: 252 Pages: 649-53. More»
  • W. A. Ritchie, T. King, Claire Neil, Ailsa Carlisle, Simon Lillico, G. McLachlan, C. B. Whitelaw. 2009. Transgenic sheep designed for transplantation studies. Molecular Reproduction and Development Vol: 76 Pages: 61-64. More»
  • Daniel F Carlson, Spring Tan, Simon G Lillico, Dana Stverakova, Christopher Proudfoot, Michelle Christian, Daniel F Voytas, Charles R Long, C Bruce A Whitelaw, Scott C Fahrenkrug. 2012. Efficient TALEN-mediated gene knockout in livestock. Proceedings of the National Academy of Sciences Vol: 109 Pages: 17382-7. More»
  • Bruce Whitelaw. 2005. Development of Germline Manipulation Technologies in Livestock. More»
  • C. J. Palgrave, Z. H. Lu, C. S. Lowden, C. B. A. Whitelaw. 2011. Dynein light chain 1 (LC8) sequence is highly conserved between pig species. Animal Genetics Vol: 42 Pages: 337-337. More»
  • C Bruce A Whitelaw, Pippa A Radcliffe, William A Ritchie, Ailsa Carlisle, Fiona M Ellard, Romi N Pena, Jo Rowe, A John Clark, Tim J King, Kyriacos A Mitrophanous. 2004. Efficient generation of transgenic pigs using equine infectious anaemia virus (EIAV) derived vector. FEBS Letters Vol: 571 Pages: 233-6. More»
  • C Bruce A Whitelaw, Akshay Joshi, Satish Kumar, Simon G Lillico, Christopher Proudfoot. 2016. Genetically engineering milk. Journal of Dairy Research Vol: 83 Pages: 3-11. More»
  • C B Whitelaw, J Webster. 1998. Temporal profiles of appearance of DNase I hypersensitive sites associated with the ovine beta-lactoglobulin gene differ in sheep and transgenic mice. Molecular & general genetics Vol: 257 Pages: 649-54. More»
  • S C Fahrenkrug, S G Lillico, C Proudfoot, T J King, J H Pryor, C R Long, C B A Whitelaw, D F Carlson. 2013. 95 production of gene-edited pigs, cattle, and lambs by embryo injection of TALENS or ZFNs. Reproduction, Fertility and Development Vol: 26 Pages: 161. More»
  • D. A. Hume, C. B. A. Whitelaw, A. L. Archibald. 2011. The future of animal production: improving productivity and sustainability. Journal of Agricultural Science Vol: 149 Pages: 9-16. More»
  • A F Kolb, J Webster, C B Whitelaw, S G Siddell. 2001. A virus-neutralising monoclonal antibody expressed in the milk of transgenic mice. Advances in Experimental Medicine and Biology Vol: 494 Pages: 411-4. More»
  • Ramona N Pena, John Webster, Stephen Kwan, Jan Korbel, Bruce A Whitelaw. 2004. Transgene methylation in mice reflects copy number but not expression level. Molecular Biotechnology Vol: 26 Pages: 215-20. More»
  • A J CLARK, H BESSOS, J O BISHOP, P BROWN, S HARRIS, R LATHE, M MCCLENAGHAN, C PROWSE, J P SIMONS, Bruce Whitelaw, I WILMUT. 1989. EXPRESSION OF HUMAN ANTI-HEMOPHILIC FACTOR-IX IN THE MILK OF TRANSGENIC SHEEP. Bio-technology Vol: 7 Pages: 487-492. More»
  • Hiu-Gwen Tsang, Nabil Rashdan, Christopher Whitelaw, Brendan Corcoran, Kim Summers, Victoria MacRae. 2016. Large animal models of cardiovascular disease. Cell Biochemistry and Function Vol: 34 Pages: 113–132. More»
  • Rachel Young, C. R. Wolf, K. Brown, J. D. Hayes, C. B. A. Whitelaw. 2010. Spatial monitoring of toxicity in HMOX-LacZ transgenic mice. Transgenic Research Vol: 19 Pages: 897-902. More»
  • D B Vasey, S G Lillico, H M Sang, T J King, C B A Whitelaw. 2009. CMV enhancer-promoter is preferentially active in exocrine cells in vivo. Transgenic Research Vol: 18 Pages: 309-14. More»
  • Christine Burkard, Simon Lillico, Elizabeth Reid, Ben Jackson, Alan J. Mileham, Tahar Ait-Ali, Christopher Whitelaw, Alan Archibald. 2017. Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function. Plos pathogens Vol: 13. More»
  • C B A Whitelaw, L Hiripi, E Farini, M L Opsahl, Z Bosze. 2004. On the use of post-transcriptional processing elements in transgenes. Transgenic Research Vol: 13 Pages: 75-9. More»
  • Wenfang Tan, Christopher Proudfoot, Simon Lillico, Christopher Whitelaw. 2016. Gene targeting, genome editing: from Dolly to editors. Transgenic Research Vol: 25 Pages: 273-287. More»
  • B Langley, J L Vilotte, M G Stinnakre, C B Whitelaw, P J L'Huillier. 1998. Rescue of an MMTV transgene by co-integration reveals novel locus control properties of the ovine beta-lactoglobulin gene that confer locus commitment to heterogeneous tissues. Transgenic Research Vol: 7 Pages: 205-12. More»
  • Alison J Thomson, Hadrien Pierart, Stephen Meek, Alexandra Bogerman, Linda Sutherland, Helen Murray, Edward Mountjoy, Alison Downing, Richard Talbot, Chiara Sartori, C Bruce A Whitelaw, Tom C Freeman, Alan L Archibald, Tom Burdon. 2012. Reprogramming Pig Fetal Fibroblasts Reveals a Functional LIF Signaling Pathway. Cellular Reprogramming Vol: 14 Pages: 112-122. More»
  • C Bruce A Whitelaw. 2013. Toward Ovine iPSCs. Cellular Reprogramming Vol: 15 Pages: 385-8. More»
  • Bruce Whitelaw, J Webster, P Kastanis, E Farini, F Osman, R Kaempfer, L Hiripi, S Bosze. 2001. Potential to exploit RNA processing elements in transgenic mice.. Cloning and Stem Cells Vol: 3 Pages: 170. More»
  • Su-Ping Chang, Margaret L Opsahl, C Bruce A Whitelaw, Steven D Morley, John D West. 2013. Relative transgene expression frequencies in homozygous versus hemizygous transgenic mice. Transgenic Research Vol: 22 Pages: 1143-1154. More»
  • M L Opsahl, M McClenaghan, A Springbett, S Reid, R Lathe, A Colman, C B A Whitelaw. 2002. Multiple effects of genetic background on variegated transgene expression in mice. Genetics Vol: 160 Pages: 1107-1112. More»
  • Monica Hoyos-Flight, Emilie Brady, Helen Sang, Bruce Whitelaw. 2017. Genome Editing and the Future of Farming meeting report. Transgenic Research Vol: 26 Pages: 319-321. More»
  • S. C. Fahrenkrug, A. Blake, D. F. Carlson, T. Doran, A. Van Eenennaam, D. Faber, C. Galli, Q. Gao, P. B. Hackett, N. Li, E. A. Maga, W. M. Muir, J. D. Murray, D. Shi, R. Stotish, E. Sullivan, J. F. Taylor, M. Walton, M. Wheeler, B. Whitelaw, B. P. Glenn. 2010. Precision genetics for complex objectives in animal agriculture. Journal of Animal Science Vol: 88 Pages: 2530-2539. More»
  • Ki-Eun Park, Amy V. Kaucher, Anne Powell, Muhamad Salman Waqas, Shelley E.S. Sandmaier, Melissa J. Oatley, Chi-Hun Park, Ahmed Tibary, David M. Donovan, Le Ann Blomberg, Simon Lillico, Christopher Whitelaw, Alan Mileham, Bhanu Telugu, Jon M. Oatley. 2017. Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene. Scientific Reports Vol: 7. More»
  • M L Opsahl, A Springbett, R Lathe, A Colman, M McClenaghan, C B A Whitelaw. 2003. Mono-allelic expression of variegating transgene locus in the mouse. Transgenic Research Vol: 12 Pages: 661-669. More»
  • Neil C. W. Mackenzie, Simon Lillico, K. Brown, C. R. Wolf, C. B. A. Whitelaw. 2010. Evaluation of RNA-knockdown strategies for modulation of cytochrome P450 reductase activity in mouse hepatocytes. Journal of RNAi and Gene Silencing. Vol: 6 Pages: 416-421. More»
  • I. Wilmut, Alan Archibald, S. Harris, M. Mcclenaghan, J.p. Simons, Bruce Whitelaw, A.j. Clark. 1990. Methods of gene transfer and their potential use to modify milk composition. Theriogenology Vol: 33 Pages: 113-123. More»
  • I Sola, J Castilla, B Pintado, J M Sánchez-Morgado, C B Whitelaw, A J Clark, L Enjuanes. 1998. Transgenic mice secreting coronavirus neutralizing antibodies into the milk. Journal of Virology Vol: 72 Pages: 3762-72. More»
  • R Pena, Bruce Whitelaw. 2002. Recombinant protein production in milk.. Biological Sciences Review Vol: 15 Pages: 39-41. More»
  • Zuyong He, Xuan Shi, Meirui Liu, Guangjie Sun, Christopher Proudfoot, Christopher Whitelaw, Simon Lillico, Yaosheng Chen. 2016. Comparison of surrogate reporter systems for enrichment of cells with mutations induced by genome editors. Journal of Biotechnology Vol: 221 Pages: 49-54. More»
  • Simon Lillico, Christopher Proudfoot, D. F. Carlson, Dana Stverakova, Claire Neil, Carol Blain, Tim King, WA Ritchie, Spring Tan, A Mileham, D Mclaren, Scott C Fahrenkrug, Bruce Whitelaw. 2013. Live pigs produced from genome edited zygotes. Scientific Reports Vol: 3 Pages: 1-4. More»
  • John Clark, Bruce Whitelaw. 2003. A future for transgenic livestock. Nature Reviews Genetics Vol: 4 Pages: 825-833. More»
  • H.M. Hodgkiss-Geere, David Argyle, Brendan Corcoran, B. Whitelaw, E. Milne, D. Bennett, Sally Argyle. 2012. Characterisation and cardiac directed differentiation of canine adult cardiac stem cells. Veterinary Journal Vol: 191 Pages: 176-182. More»
  • Simon Lillico, D. Vasey, Tim King, B. Whitelaw. 2011. Lentiviral transgenesis in livestock. Transgenic Research Vol: 20 Pages: 441-442. More»
  • C. Sartori, A.I. Didomenico, A.J. Thomson, E. Milne, S.G. Lillico, T.G. Burdon, C.B. Whitelaw. 2012. Ovine-Induced Pluripotent Stem Cells Can Contribute to Chimeric Lambs. Cellular Reprogramming Vol: 14 Pages: 8-19. More»
  • Alan Archibald, A. J. Clark, S. Harris, M McClenaghan, J. P. Simons, Bruce Whitelaw. 1998. Transgenic constructs with some (but not all) introns.. More»
  • Serap Gonen, Janez Jenko, Gregor Gorjanc, Alan J Mileham, Christopher Whitelaw, John Hickey. 2017. Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs. Genetics Selection Evolution Vol: 49. More»
  • Christopher Whitelaw. 2016. The Genome Editing Revolution in Livestock Marches on. Human Mutation Vol: 37 Pages: 5. More»
  • C Bruce A Whitelaw, Donald M Bruce. 2002. Does genetic modification violate intrinsic value?. Trends in biotechnology Vol: 20 Pages: 488-9. More»
  • R M Tywman, Bruce Whitelaw. 2000. Genetic engineering: Animal cell technology. More»
  • S Grolli, P Accornero, R Ramoni, G Donofrio, C B Whitelaw. 1997. Expression of c-myc is down-regulated as mouse mammary epithelial cells become confluent. Biochemical and Biophysical Research Communications Vol: 239 Pages: 566-9. More»
  • Corinne Kostic, Tim King, Sylvain V Crippa, Stephanie Philippe, Simon Lillico, Chamsy Sarkis, Jacques Mallet, Yvan Arsenijevic, Bruce Whitelaw. 2012. Analysis Of Photoreceptor Abnormality In Gucy2d E837D/R838S Transgenic Pigs. More»
  • I. Wilmut, A. L. Archibald, M. Mcclenaghan, J. P. Simons, C. B. A. Whitelaw, A. J. Clark. 1991. Production of pharmaceutical proteins in milk. Experientia Vol: 47 Pages: 905-912. More»
  • Corinne Kostic, Simon Geoffrey Lillico, Sylvain Vincent Crippa, Nicolas Grandchamp, Héloïse Pilet, Stéphanie Philippe, Zen Lu, Tim James King, Jacques Mallet, Chamsy Sarkis, Yvan Arsenijevic, Christopher Bruce Alexander Whitelaw. 2013. Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy. PLoS ONE Vol: 8 Pages: e71363. More»
  • Luise A Seeker, Rebecca Holland, Sarah Underwood, Jennifer Fairlie, Androniki Psifidi, Joanna Warner, Ainsley Bagnall, Bruce Whitelaw, Mike Coffey, Georgios Banos, Daniel Nussey. 2016. Method specific calibration corrects for DNA extraction method effects on relative telomere length measurements by quantitative PCR. PLoS ONE Vol: 11. More»
  • I Wilmut, C B Whitelaw. 1994. Strategies for production of pharmaceutical proteins in milk. Reproduction, Fertility and Development Vol: 6 Pages: 625-30. More»
  • Bruce Whitelaw, Alan Archibald, M McClenaghan, S. Harris, J. P. Simons, C J Watson, Ian Wilmut, A. J. Clark. 1990. Expression of ß-lactoglobulin and hybrid transgenes in the mammary gland.. Proc Biotech USA Pages: 130-136. More»
  • Z.H. Lu, A. Di Domenico, S.H. Wright, P.A. Knight, C.B.A. Whitelaw, A.D. Pemberton. 2011. Strain-specific copy number variation in the intelectin locus on the 129 mouse chromosome 1. BMC Genomics Vol: 12. More»
  • Corinne Kostic, Verene Pignat, Bruce Whitelaw, Heloise Pilet, Suzanne Ursulet, Sebastien Dussaud, Yvan Arsenijevic, Chamsy Sarkis. 2011. Mice Transgenic For Human Dominant Mutations Of The GUCY2D Gene. More»
  • Elizabeth Tonner, Michael C Barber, Gordon J Allan, James Beattie, John Webster, C Bruce A Whitelaw, David J Flint. 2002. Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice. Development Vol: 129 Pages: 4547-57. More»
  • J Webster, G Donofrio, R Wallace, A J Clark, C B Whitelaw. 1997. Intronic sequences modulate the sensitivity of beta-lactoglobulin transgenes to position effects. Gene Vol: 193 Pages: 239-43. More»
  • Mark Arends, Eric White, Christopher Whitelaw. 2016. Animal and cellular models of human disease. The Journal of Pathology Vol: 238 Pages: 137-140. More»
  • C. Bruce A. Whitelaw, Timothy P. Sheets, Simon G. Lillico, Bhanu P. Telugu. 2016. Engineering large animal models of human disease: Domesticated Animal Models of Human Disease. The Journal of Pathology Vol: 238 Pages: 247-256. More»
  • Jane Gebbie, Christopher Whitelaw. 2016. The New R: How an Animal Welfare and Ethical Review Body in the UK Is Tackling Reproducibility. More»
  • C B Whitelaw. 1996. Truncated beta-lactoglobulin transgenes are expressed in the kidney. Gene Vol: 178 Pages: 157-9. More»
  • Bruce Whitelaw, A. J. Clark. 1989. Animal bioreactors.. AgBiotech News and Information Vol: 1 Pages: 701-705. More»
  • J. P. Simons, S. Ali, Alan Archibald, P. Brown, S. Harris, M McClenaghan, Bruce Whitelaw, Ian Wilmut, A. J. Clark. 1990. Modification of milk composition by gene transfer. More»
  • Margaret L Opsahl, Margaret McClenaghan, Anthea Springbett, Sarah Reid, Richard Lathe, Alan Colman, C Bruce A Whitelaw. 2002. Multiple effects of genetic background on variegated transgene expression in mice. Genetics Vol: 160 Pages: 1107-12. More»
  • C B Whitelaw, A L Archibald, S Harris, M McClenaghan, J P Simons, A J Clark. 1991. Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic mice. Transgenic Research Vol: 1 Pages: 3-13. More»
  • Yvan Arsenijevic, Tim King, Sylvain V Crippa, Simon Lillico, Chamsy Sarkis, Jacques Mallet, Corinne Kostic, Bruce Whitelaw. 2011. Pigs Transgenic For Human Dominant Mutations Of The GUCY2D Gene. More»
  • K.R. Upton, C. Pridans, S. Meek, L. Sutherland, B. Whitelaw, T. Burdon, D. Hume. 2011. Gene targeting of the rat Csf1r locus using homologous recombination in ES cells. More»