Dr Darren Shaw

The Royal (Dick) School of Veterinary Studies/The Roslin Institute

Research Interests

I am interested in wildlife zoonoses and in particular the role of carnivores as sentinels for disease, and part of this stems from a long standing interest in analysing patterns of disease as well as general population dynamics. I also have a major interest in diseases of veterinary and medical importance. Two long term foci of interest have been enterobacteriaecae (Verocytotoxic and antibiotic resistant Escherichia coli and Salmonellae) in both bovine and human hosts, and the analysis of the spread of foot and mouth disease. However, I also focus on clinical epidemiology and as such I work closely with clinical colleagues on various veterinary diseases (e.g. tuberculosis, wildlife pathogens, mastitis) as well as general aspects of animal health (e.g. equine reproduction and laminitis, feline cardiology).

Selected Publications

  • Amin Tahoun, Simmi Mahajan, Edith Paxton, Georg Malterer, David S Donaldson, Dai Wang, Alwyn Tan, Trudi L Gillespie, Marie O'Shea, Andrew J Roe, Darren J Shaw, David L Gally, Andreas Lengeling, Neil A Mabbott, Juergen Haas, Arvind Mahajan. 2012. Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion. Cell Host and Microbe Vol: 12 Pages: 645-56. More»
  • Xuefang Xu, Sean P McAteer, Jai J Tree, Darren J Shaw, Eliza B K Wolfson, Scott A Beatson, Andrew J Roe, Lesley J Allison, Margo E Chase-Topping, Arvind Mahajan, Rosangela Tozzoli, Mark E J Woolhouse, Stefano Morabito, David L Gally. 2012. Lysogeny with Shiga Toxin 2-Encoding Bacteriophages Represses Type III Secretion in Enterohemorrhagic Escherichia coli. PLoS Pathogens Vol: 8. More»
  • G McLachlan, H Davidson, E Holder, L A Davies, I A Pringle, S G Sumner-Jones, A Baker, P Tennant, C Gordon, C Vrettou, R Blundell, L Hyndman, B Stevenson, A Wilson, A Doherty, D J Shaw, R L Coles, H Painter, S H Cheng, R K Scheule, J C Davies, J A Innes, S C Hyde, U Griesenbach, E W F W Alton, A C Boyd, D J Porteous, D R Gill, D D S Collie. 2011. Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung. Gene Therapy Vol: 18 Pages: 996-1005. More»
  • A.F. Flockhart, J.J. Tree, X. Xu, M. Karpiyevich, S.P. McAteer, R. Rosenblum, D.J. Shaw, C.J. Low, A. Best, V. Gannon, C. Laing, K.C. Murphy, J.M. Leong, T. Schneiders, R. La Ragione, D.L. Gally. 2012. Identification of a novel prophage regulator in Escherichia coli controlling the expression of type III secretion. Molecular Microbiology Vol: 83 Pages: 208-223. More»
  • K.G. Snedeker, D.J. Shaw, M.E. Locking, R.J. Prescott. 2009. Primary and secondary cases in Escherichia coli O157 outbreaks: a statistical analysis. BMC Infectious Diseases Vol: 9. More»
  • R. Deardon, S.P. Brooks, B.T. Grenfell, M.J. Keeling, M.J. Tildesley, N.J. Savill, D.J. Shaw, M.E.J. Woolhouse. 2010. Inference for individual-level models of infectious diseases in large populations. Statistica Sinica Vol: 20 Pages: 239-261. More»
  • C. Oddsdottir, S.C. Riley, R. Leask, D.J. Shaw, C. Aurich, F. Palm, A.L. Fowden, S.W. Ricketts, E.D. Watson. 2011. Dynamics of activities of matrix metalloproteinases-9 and-2, and the tissue inhibitors of MMPs in fetal fluid compartments during gestation and at parturition in the mare. Theriogenology Vol: 75 Pages: 1130-1138. More»
  • Paul Bessell, D. J. Shaw, N. J. Savill, M. E. J. Woolhouse. 2008. Geographic and topographic determinants of local FMD transmission applied to the 2001 UK FMD epidemic. BMC Veterinary Research Vol: 4. More»