Dr David Collie

The Roslin Institute

Research Interests

Our group has a longstanding interest in developing a closer understanding of the mechanisms that underlay lung disease in domestic animals and man such that appropriate directed therapies can be developed and validated in a pre-clinical setting prior to their evaluation in a clinical context.

Current emphasis is largely directed towards developing lung-directed gene therapy as a viable clinical entity. The driver in this instance is our involvement as a core facility within the UK Cystic Fibrosis Gene Therapy Consortium, a grouping of the leading gene therapists in the UK and whose focus is a major UK initiative to conduct the largest ever human gene therapy trial for this condition.

Our current interests also extend to understanding the molecular and cellular mechanisms underlying airway epithelial repair in response to injury and exploring novel therapeutic concepts in this regard. Whilst repair mechanisms involving a range of processes including cellular dedifferentiation, migration, and re-differentiation or transition, are usually very efficient in the normal lung, they are clearly overwhelmed in the context of such chronic diseases as cystic fibrosis, COPD and asthma. With the ever rising burden of such chronic lung disease in the UK the need for developing original therapeutic angles and validating those approaches using relevant model systems is clear.

Selected Publications

  • E. W. Alton, Alison Baker, Eilidh Baker, Christopher Boyd, S. H. Cheng, Rebecca Coles, David Collie, Heather Davidson, Jane C Davies, D. R. Gill, Catherine Gordon, U. Griesenbach, T. Higgins, S. C. Hyde, J. A. Innes, Dominique McCormick, Michael McGovern, Gerry McLachlan, David Porteous, I. A. Pringle, R. K. Scheule, Darren Shaw, Sionagh Smith, Stephanie Summer-Jones, Peter Tennant, Christina Vrettou. 2013. The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep. Biomaterials Vol: 34 Pages: 10267-10277. More»
  • David Collie, John Govan, Steven Wright, Elisabeth Thornton, Peter Tennant, Sionagh Smith, Catherine Doherty, Gerry McLachlan. 2013. A Lung Segmental Model of Chronic Pseudomonas Infection in Sheep. PLoS One Vol: 8. More»
  • Badrul Yahaya, Gerry McLachlan, Caroline McCorquodale, David Collie. 2013. Gene Expression Changes Associated with the Airway Wall Response to Injury. PLoS One Vol: 8. More»
  • G McLachlan, H Davidson, E Holder, L A Davies, I A Pringle, S G Sumner-Jones, A Baker, P Tennant, C Gordon, C Vrettou, R Blundell, L Hyndman, B Stevenson, A Wilson, A Doherty, D J Shaw, R L Coles, H Painter, S H Cheng, R K Scheule, J C Davies, J A Innes, S C Hyde, U Griesenbach, E W F W Alton, A C Boyd, D J Porteous, D R Gill, D D S Collie. 2011. Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung. Gene Therapy Vol: 18 Pages: 996-1005. More»
  • Tom N McNeilly, Alison Baker, Jeremy K Brown, David Collie, Gerry McLachlan, Susan M Rhind, Gordon D Harkiss. 2008. Role of Alveolar Macrophages in Respiratory Transmission of Visna/Maedi Virusâ–ż. Journal of Virology Vol: 82 Pages: 1526-1536. More»
  • U. Griesenbach, G. McLachlan, T. Owaki, L. Somerton, T. Shu, A. Baker, P. Tennant, C. Gordon, C. Vrettou, E. Baker, D. D. S. Collie, M. Hasegawa, E. W. F. W. Alton. 2011. Validation of recombinant Sendai virus in a non-natural host model. Gene Therapy Vol: 18 Pages: 182-188. More»
  • B. Yahaya, A. Baker, Peter Tennant, Sionagh Smith, D.J. Shaw, G. McLachlan, D.D. Collie. 2011. Analysis of airway epithelial regeneration and repair following endobronchial brush biopsy in sheep. Experimental Lung Research Vol: 37 Pages: 519-535. More»
  • H. Davidson, A. Wilson, R. D. Gray, A. Horsley, I. A. Pringle, G. McLachlan, A. C. Nairn, C. Stearns, J. Gibson, E. Holder, L. Jones, A. Doherty, R. Coles, S. G. Sumner-Jones, M. Wasowicz, M. Manvell, U. Griesenbach, S. C. Hyde, D. R. Gill, J. Davies, D. D. S. Collie, Ewfw Alton, D. J. Porteous, A. C. Boyd. 2009. An immunocytochemical assay to detect human CFTR expression following gene transfer. Molecular and Cellular Probes Vol: 23 Pages: 272-280. More»