The research in our group revolves around the cellular and molecular biology of macrophages. Macrophages are major cellular effectors of innate immunity and inflammation, but are also involved in normal growth and development and tissue repair. Our research involves the use of cell and molecular biological approaches, on genome-wide scale, to understand how these cells differentiate from their common precursors in the bone marrow under the influence of factors such as macrophage colony-stimulating factor (CSF-1) and interleukin 34 (IL34), how mature cells of this lineage are able to respond to environmental signals such as microorganisms, and their functions in normal embryological development and postnatal growth. This research utilises transgenic reporter genes in a range of species including mouse, rat, chicken, sheep and pig. We are especially interested in comparative analysis of the way that macrophages recognise potential pathogens, the way that function has evolved between species, and how it varies amongst individuals within a species. Our research utilises mouse, rat, chicken, dog, cat, sheep, cattle, pig and human systems to investigate different aspects of macrophage biology.
The laboratory coordinates a BBSRC-funded resource of information on macrophage biology, gene regulation and gene function at www.macrophages.com
David A. Hume and 45 others. 2010. An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man. Cell Vol: 140 Pages: 744-752. More»
Kate Schroder, Katharine M Irvine, Martin S Taylor, Nilesh J Bokil, Kim-Anh Le Cao, Kelly-Anne Masterman, Larisa I Labzin, Colin A Semple, Ronan Kapetanovic, Lynsey Fairbairn, Altuna Akalin, Geoffrey J Faulkner, John Kenneth Baillie, Milena Gongora, Carsten O Daub, Hideya Kawaji, Geoffrey J McLachlan, Nick Goldman, Sean M Grimmond, Piero Carninci, Harukazu Suzuki, Yoshihide Hayashizaki, Boris Lenhard, David A Hume, Matthew J Sweet. 2012. Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences Vol: 109 Pages: E944-E953. More»
Tara L. Roberts, Adi Idris, Jasmyn A. Dunn, Greg M. Kelly, Carol M. Burnton, Samantha Hodgson, Lani L. Hardy, Valerie Garceau, Matthew J. Sweet, Ian L. Ross, David A. Hume, Katryn J. Stacey. 2009. HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA. Science Vol: 323 Pages: 1057-1060. More»
Kelli P A MacDonald, James S Palmer, Stephen Cronau, Elke Seppanen, Stuart Olver, Neil C Raffelt, Rachel Kuns, Allison R Pettit, Andrew Clouston, Brandon Wainwright, Dan Branstetter, Jeffrey Smith, Raymond J Paxton, Douglas Pat Cerretti, Lynn Bonham, Geoffrey R Hill, David A Hume. 2010. An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation. Blood Vol: 116 Pages: 3955-3963. More»