The Grey Lab uses cutting-edge tools to examine the interactions between the host and pathogens such as cytomegalovirus, influenza virus and African Trypanosomiasis.
Pathogens interact with hosts in complex and intricate ways. Understanding how pathogens interact with the host can provide valuable information on how the pathogen replicates and teach us how the host responds to infections, ultimately leading to the development of better vaccines, drugs and treatment regimes. Systematic high throughput screens are powerful approaches that allow us to examine the role of host genes during infection.
Our group uses cutting-edge high throughput approaches including small interfering RNA (siRNA) and CRISPR/Cas9 screens, arrayed interferon stimulated gene (ISG) expression libraries and microRNA target identification to discover and characterise novel host-pathogen interactions. We work on human clinical diseases including human cytomegalovirus, diseases important to livestock, and pathogens that span both human and livestock, such as influenza virus and African Trypanosomiasis.
Lauren M Hook, Finn Grey, Robert Grabski, Rebecca Tirabassi, Tracy Doyle, Meaghan Hancock, Igor Landais, Sophia Jeng, Shannon McWeeney, William Britt, Jay A Nelson. 2014. Cytomegalovirus miRNAs Target Secretory Pathway Genes to Facilitate Formation of the Virion Assembly Compartment and Reduce Cytokine Secretion. Cell Host and Microbe Vol: 15 Pages: 363-73. More»
Jonathan Pavelin, Natalie Reynolds, Stephen Chiweshe, Guanming Wu, Rebecca Tiribassi, Finn Grey. 2013. Systematic MicroRNA Analysis Identifies ATP6V0C as an Essential Host Factor for Human Cytomegalovirus Replication. Plos pathogens Vol: 9 Pages: e1003820. More»
Finn Grey, Rebecca Tirabassi, Heather Meyers, Guanming Wu, Shannon McWeeney, Lauren Hook, Jay A. Nelson. 2010. A Viral microRNA Down-Regulates Multiple Cell Cycle Genes through mRNA 5 ' UTRs. Plos pathogens Vol: 6 Pages: -. More»
V. Libri, A. Helwak, P. Miesen, D. Santhakumar, J.G. Borger, G. Kudla, F. Grey, D. Tollervey, A.H. Buck. 2012. Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target. Proceedings of the National Academy of Sciences Vol: 109 Pages: 279-284. More»