Dr Jayne Hope

The Roslin Institute

Research Interests

The group focuses on cellular immune responses aiming to define the mechanisms whereby natural immunity is achieved and how protective immunity is induced by vaccination. We focus specifically on antigen presenting cells and their interactions with other cells of the innate immune system including natural killer cells and gamma delta TCR+ T lymphocytes. The overall aim is to define the functional and phenotypic characteristics of innate immune cells and to assess their role in protective immunity to mycobacterial pathogens including Mycobacterium bovis and M. avium paratuberculosis. These pathogens cause economically important diseases in cattle: bovine tuberculosis and Johne’s disease. Alongside this we are interested in defining host-pathogen interactions in feline tuberculosis. Effective control of mycobacterial diseases requires the development of effective vaccines and/or diagnostic tests: this requires detailed knowledge of protective immune mechanisms. The development of new immunological tools, reagents and assays and validation across species is also an important area of research. This will provide the capacity to determine immunological correlates of protection against a number of strategically important diseases.

Selected Publications

  • E. Guzman, C. Cubillos-Zapata, M. G. Cottingham, S. C. Gilbert, H. Prentice, B. Charleston, J. C. Hope. 2012. Modified Vaccinia Virus Ankara-Based Vaccine Vectors Induce Apoptosis in Dendritic Cells Draining from the Skin via both the Extrinsic and Intrinsic Caspase Pathways, Preventing Efficient Antigen Presentation. Journal of Virology Vol: 86 Pages: 5452-5466. More»
  • Jayne Hope, E. Guzman, C. Cubillos-Zapata, S.A. Stephens, S.C. Gilbert, H. Prentice, P. Sopp, C.J. Howard, B. Charleston. 2012. Migratory sub-populations of afferent lymphatic dendritic cells differ in their interactions with Mycobacterium bovis Bacille Calmette Guerin. Vaccine Vol: 30 Pages: 2357-2367. More»
  • C. Cubillos-Zapata, E. Guzman, A. Turner, S.C. Gilbert, H. Prentice, J.C. Hope, B. Charleston. 2011. Differential Effects of Viral Vectors on Migratory Afferent Lymph Dendritic Cells In Vitro Predict Enhanced Immunogenicity In Vivo. Journal of Virology Vol: 85 Pages: 9385-9394. More»
  • P. Sopp, M. Coad, G. Hewinson, C.J. Howard, C.N. Cheallaigh, J. Keane, J. Harris, J.C. Hope. 2008. Development of a simple, sensitive, rapid test which discriminates BCG-vaccinated from Mycobacterium bovis-infected cattle. Vaccine Vol: 26 Pages: 5470-5476. More»