Professor Liz Glass

The Roslin Institute

Research Interests

The main aim of the Liz Glass lab is to improve the ability of livestock to withstand infection with pathogens by breeding more disease resistant livestock and by improving vaccine efficacy.  The group is focusing on early host-pathogen interactions as these likely determine the outcome of exposure to pathogens and vaccines, leading to protection or pathology. Currently the research team is mainly focusing on bovine tuberculosis (bTB) caused by the bacterium, Mycobacterium bovis, which resides within host bovine macrophages. Approaches include transcriptomics and functional assays to uncover the cellular and molecular pathways induced by infection in vitro.  Understanding their relationship to variable outcomes in vivo, could identify novel innate immune correlates of protection and thus aid the design of more effective vaccines. The group is also exploring the genetic basis of variation in the host’s response to infection by locating the genes involved, through SNP based whole genome association studies.  Understanding how variation in genes controlling immunity impacts on infection could identify new ways to direct the immune response for more robust host defence.

By identifying genetic markers of resistance and susceptibility, this translational research has the potential to impact on livestock breeding decisions to reduce the risk of individual animals contracting infections.  The research may also provide new avenues to modulate and direct immunity and thus influence vaccine design.

The research is funded mainly by the BBSRC and various industry sponsors.

Selected Publications

  • Kirsty Jensen, Iain Gallagher, Anna Kaliszewska, Chen Zhang, Oluyinka Abejide, Maurice Gallagher, Dirk Werling, Elizabeth Glass. 2016. Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells. Veterinary Research Vol: 47 Pages: 46. More»
  • Yolanda Corripio-Miyar, Jayne Hope, Colin J McInnes, Sean R Wattegedera, Kirsty Jensen, Yvonne Pang, Gary Entrican, Elizabeth J Glass. 2015. Phenotypic and functional analysis of monocyte populations in cattle peripheral blood identifies a subset with high endocytic and allogeneic T-cell stimulatory capacity. Veterinary Research Vol: 46. More»
  • Efstathios S. Giotis, Lisa Rothwell, Alistair Scott, Tuanjun Hu, Richard Talbot, Daniel Todd, David W. Burt, Elizabeth J. Glass, Pete Kaiser. 2015. Transcriptomic Profiling of Virus-Host Cell Interactions following Chicken Anaemia Virus (CAV) Infection in an In Vivo Model. PLoS ONE Vol: 10. More»
  • Amin Tahoun, Kirsty Jensen, Yolanda Corripio-Miyar, Sean P. McAteer, Alexander Corbishley, Arvind Mahajan, Helen Brown, David Frew, Aude Aumeunier, David G E Smith, Tom N. McNeilly, Elizabeth J. Glass, David L. Gally. 2015. Functional analysis of bovine TLR5 and association with IgA responses of cattle following systemic immunisation with H7 flagella. Veterinary Research Vol: 46. More»
  • M. L. Bermingham, S. C. Bishop, J. A. Woolliams, R. Pong-Wong, A. R. Allen, S. H. McBride, J. J. Ryder, D. M. Wright, R. A. Skuce, S. W. J. McDowell, E. J. Glass. 2014. Genome-wide association study identifies novel loci associated with resistance to bovine tuberculosis. Heredity Vol: 112 Pages: 543-551. More»
  • Elizabeth J. Glass, Kirsty Jensen and 49 others. 2009. The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution. Science Vol: 324 Pages: 522-528. More»
  • K. Jensen, G. D. Makins, A. Kaliszewska, M. J. Hulme, E. Paxton, E. J. Glass. 2009. The protozoan parasite Theileria annulata alters the differentiation state of the infected macrophage and suppresses musculoaponeurotic fibrosarcoma oncogene (MAF) transcription factors. Int J Parasitol Vol: 39 Pages: 1099-108. More»
  • O. C. Jann, A. King, N. L. Corrales, S. I. Anderson, K. Jensen, T. Ait-Ali, H. Tang, C. Wu, N. E. Cockett, A. L. Archibald, E. J. Glass. 2009. Comparative genomics of Toll-like receptor signalling in five species. BMC Genomics Vol: 10. More»