Dr Lonneke Vervelde

The Roslin Institute

Research Interests

My research group has investigated the immune responses to pathogens and vaccines in poultry with the ultimate goal to enhance immune-mediated resistance and thus improving the welfare of the animals. The overall aim is to determine how the early innate responses modulate the adaptive responses and assess their role in the induction of protective immunity, particularly at musosal surfaces. The research focuses on economically important pathogens such as avian influenza virus, infectious bronchitis virus and Eimeria species.

Next to unravelling the basic host-pathogen interactions, the work included improvement of mucosal vaccination through antigen targeting and adjuvants and enhancement of gut health through feed additives.

The development of new immunological tools, reagents and assays for avian immunology is another area of research. This will provide means to investigate fundamental immunological knowledge and determine immunological correlates of protection against avian diseases.

Selected Publications

  • Kate M C Sutton, Jun Hu, Zhiguang Wu, Botond Siklodi, Lonneke Vervelde, Pete Kaiser. 2015. The functions of the avian receptor activator of NF-κB ligand (RANKL) and its receptors, RANK and osteoprotegerin, are evolutionarily conserved. Developmental and Comparative Immunology Vol: 51 Pages: 170-184. More»
  • Eveline D de Geus, Winfried G J Degen, Daphne A van Haarlem, Carla Schrier, Femke Broere, Lonneke Vervelde. 2015. Distribution patterns of mucosally applied particles and characterization of the antigen presenting cells. Avian Pathology Vol: 44 Pages: 222-229. More»
  • Valerie Garceau, Adam Balic, Carla Garcia-Morales, Kristin A Sauter, Mike J McGrew, Jacqueline Smith, Lonneke Vervelde, Adrian Sherman, Troy E Fuller, Theodore Oliphant, John A Shelley, Raksha Tiwari, Thomas L Wilson, Cosmin Chintoan-Uta, Dave W Burt, Mark P Stevens, Helen M Sang, David A Hume. 2015. The development and maintenance of the mononuclear phagocyte system of the chick is controlled by signals from the macrophage colony-stimulating factor (CSF1) receptor. BMC Biology Vol: 13 Pages: 121. More»
  • Carla Garcia-Morales, Sunil Nandi, Debiao Zhao, Kristin A Sauter, Lonneke Vervelde, Derek McBride, Helen M Sang, Mike Clinton, David A Hume. 2015. Cell-Autonomous Sex Differences in Gene Expression in Chicken Bone Marrow-Derived Macrophages. Journal of Immunology Vol: 194 Pages: 2338-2344. More»
  • Suresh V Kuchipudi, Meenu Tellabati, Sujith Sebastian, Brandon Z Londt, Christine Jansen, Lonneke Vervelde, Sharon M Brookes, Ian H Brown, Stephen P Dunham, Kin-chow Chang. 2014. Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses. Veterinary Research Vol: 45. More»
  • Klaudia Chrzastek, Dominika Borowska, Pete Kaiser, Lonneke Vervelde. 2014. Corrigendum to "Class B CpG ODN stimulation upregulates expression of TLR21 and IFN-γ in chicken Harderian gland cells" [Vet. Immunol. Immunopathol. 160 (2014) 293-299] (DOI: 10.1016/j.vetimm.2014.04.010). Veterinary Immunology and Immunopathology Vol: 161 Pages: 271. More»
  • Gudrun S Freidl, Erwin de Bruin, Janko van Beek, Johan Reimerink, Sjaak de Wit, Guus Koch, Lonneke Vervelde, Henk-Jan van den Ham, Marion P G Koopmans. 2014. Getting More Out of Less - A Quantitative Serological Screening Tool for Simultaneous Detection of Multiple Influenza A Hemagglutinin-Types in Chickens. PLoS One Vol: 9 Pages: e108043. More»
  • Klaudia Chrza̧stek, Dominika Borowska, Pete Kaiser, Lonneke Vervelde. 2014. Class B CpG ODN stimulation upregulates expression of TLR21 and IFN-ϒ in chicken Harderian gland cells. Veterinary Immunology and Immunopathology Vol: 160 Pages: 293-299. More»
  • Adam Balic, Carla Garcia-Morales, Lonneke Vervelde, Hazel Gilhooley, Adrian Sherman, Valerie Garceau, Maria Gutowska, Dave Burt, Pete Kaiser, David Hume, Helen Sang. 2014. Visualisation of chicken macrophages using transgenic reporter genes: insights into the development of the avian macrophage lineage. Development Vol: 141 Pages: 3255-3265. More»