Dr Megan Davey

The Roslin Institute

Research Interests

SEM Cilia

TALPID3, CILIA and HEDGEHOG

The localisation and function of TALPID3

The consequences of a loss of cilia during development

Regulation of Sonic Hedgehog during development

We use utilise a combination of classical genetics, anatomy, embryology and embryonic manipulation with modern molecular biology, genetic manipulation, gene expression profiling, proteomics and imaging techniques.

Selected Publications

  • Louise A Stephen, Gemma Davis, Katie E McTeir, John James, Lynn McTeir, Martin Kierans, Andrew Bain, Megan G Davey. 2013. Failure of centrosome migration causes a loss of motile cilia in talpid3 mutants. Developmental Dynamics Vol: 242 Pages: 923-931. More»
  • F. Bangs, N. Antonio, P. Thongnuek, M. Welten, M.G. Davey, J. Briscoe, C. Tickle. 2011. Generation of mice with functional inactivation of talpid3, a gene first identified in chicken. Development Vol: 138 Pages: 3261-3272. More»
  • Yili Yin, Fiona Bangs, I Robert Paton, Alan Prescott, John James, Megan G Davey, Paul Whitley, Grigory Genikhovich, Ulrich Technau, David W Burt, Cheryll Tickle. 2009. The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation. Development Vol: 136 Pages: 655-64. More»
  • Ian C Dunn, I Robert Paton, Allyson K Clelland, Sujith Sebastian, Edward J Johnson, Lynn McTeir, Dawn Windsor, Adrian Sherman, Helen Sang, Dave W Burt, Cheryll Tickle, Megan G Davey. 2011. The chicken polydactyly (Po) locus causes allelic imbalance and ectopic expression of Shh during limb development. Developmental Dynamics Vol: 240 Pages: 1163-72. More»