My research aims to understand the pathogenesis of infectious diseases within the immune system. Particular interests include understanding host-pathogen interactions within the mucosal immune system, especially prion diseases and other gastrointestinal pathogens such as Salmonella and nematodes.
Studies are also focused on the effects of host age on the function of the immune system and how this influences susceptibility to gastrointestinal pathogens.
A systems biology approach is also being used to compare the transcriptomic profiles of distinct immune cell populations in the steady-state, and also during ageing.
This research benefits greatly from the availability of precisely defined mouse prion pathogenesis models, unique transgenic and immunodeficient mice and state-of-the-art bio-imaging and bioinformatics expertise.
A Kobayashi, D S Donaldson, C Erridge, T Kanaya, I R Williams, H Ohno, A Mahajan, N A Mabbott. 2013. The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice. Mucosal Immunology Vol: 6 Pages: 1027-1037. More»
S. W. Mok, R. L. Proia, V. Brinkmann, N. A. Mabbott. 2012. B Cell-Specific S1PR1 Deficiency Blocks Prion Dissemination between Secondary Lymphoid Organs. Journal of Immunology Vol: 188 Pages: 5032-5040. More»
D.S. Donaldson, A. Kobayashi, H. Ohno, H. Yagita, I.R. Williams, N.A. Mabbott. 2012. M cell-depletion blocks oral prion disease pathogenesis. Mucosal Immunology Vol: 5 Pages: 216-225. More»
P. Kujala, C.R. Raymond, M. Romeijn, S.F. Godsave, S.I. van Kasteren, H. Wille, S.B. Prusiner, N.A. Mabbott, P.J. Peters. 2011. Prion uptake in the gut: identification of the first uptake and replication sites. PLoS Pathogens Vol: 7. More»
L. McCulloch, K.L. Brown, B.M. Bradford, J. Hopkins, M. Bailey, K. Rajewsky, J.C. Manson, N.A. Mabbott. 2011. Follicular Dendritic Cell-Specific Prion Protein (PrP) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen. PLoS Pathogens Vol: 7. More»
K.L. Brown, A. Gossner, S. Mok, N.A. Mabbott. 2012. The Effects of Host Age on the Transport of Complement-Bound Complexes to the Spleen and the Pathogenesis of Intravenous Scrapie Infection. Journal of Virology Vol: 86 Pages: 25-35. More»