My research aims to understand the pathogenesis of infectious diseases within the immune system. Particular interests include understanding host-pathogen interactions within the mucosal immune system, especially prion diseases and other gastrointestinal pathogens such as Salmonella and nematodes.
Studies are also focused on the effects of host age on the function of the immune system and how this influences susceptibility to gastrointestinal pathogens.
A systems biology approach is also being used to compare the transcriptomic profiles of distinct immune cell populations in the steady-state, and also during ageing.
This research benefits greatly from the availability of precisely defined mouse prion pathogenesis models, unique transgenic and immunodeficient mice and state-of-the-art bio-imaging and bioinformatics expertise.
Bo-Ju Shih, Ajit johnson Nirmal, Denis Headon, Arne Nalpon Akbar, Neil Mabbott, Thomas Freeman. 2017. Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders. The Journal of Pathology Vol: 241 Pages: 600-613. More»
David Donaldson, Anuj Sehgal, Daniel Rios, Ifor R Williams, Neil Mabbott. 2016. Increased Abundance of M cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility. PLoS Pathogens Vol: 12. More»
A Kobayashi, D S Donaldson, C Erridge, T Kanaya, I R Williams, H Ohno, A Mahajan, N A Mabbott. 2013. The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice. Mucosal Immunology Vol: 6 Pages: 1027-1037. More»
P. Kujala, C.R. Raymond, M. Romeijn, S.F. Godsave, S.I. van Kasteren, H. Wille, S.B. Prusiner, N.A. Mabbott, P.J. Peters. 2011. Prion uptake in the gut: identification of the first uptake and replication sites. PLoS Pathogens Vol: 7. More»
L. McCulloch, K.L. Brown, B.M. Bradford, J. Hopkins, M. Bailey, K. Rajewsky, J.C. Manson, N.A. Mabbott. 2011. Follicular Dendritic Cell-Specific Prion Protein (PrP) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen. PLoS Pathogens Vol: 7. More»