Dr Peter Hohenstein

The Roslin Institute

Research Interests

In our lab we study the link between normal kidney development and kidney disease, especially the development of Wilms’ tumours. Much work is done on the role of the Wt1 and β-catenin genes in this, and their involvement in embryonic kidney progenitor cells, but also later stages of kidney development and function are being studied. We are also interested in using the understanding of kidney development from this work to develop ways to generate early kidney progenitor cells from other cells types for kidney replacement therapy.

The use of transgenic mouse models is central in our work, and we use models that we import from other labs or generate ourselves. Besides our kidney work we also try to improve the possibilities and efficiency of transgenic techniques in mice, and the possibility of transferring them to other species.

Selected Publications

  • Mara Artibani, Andrew Sims, Joan Slight, James Aitken, Anna Thornburn, Morwenna Muir, Valerie Brunton, Jorge Del-Pozo, Linda Morrison, Elad Katz, Nicholas Hastie, Peter Hohenstein. 2017. WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel. Scientific Reports Vol: 7. More»
  • Ruthrothaselvi Bharathavikru, Tatiana Dudnakova, James Aitken, Joan Slight, Mara Artibani, Peter Hohenstein, David Tollervey, Nicholas Hastie. 2017. Transcription factor, Wilms’ Tumour 1 regulates developmental RNAs through 3’ UTR interaction.. Genes & Development Vol: 31 Pages: 347-352. More»
  • Rachel L Berry, Derya D Ozdemir, Bruce Aronow, Nils Lindstrom, Tatiana Dudnakova, Anna Thornburn, Paul Perry, Richard Baldock, Chris Armit, Anagha Joshi, Cécile Jeanpierre, Jingdong Shan, Seppo Vainio, James Baily, David Brownstein, Jamie Davies, Nicholas D Hastie, Peter Hohenstein. 2015. Deducing the stage of origin of Wilms tumours from a developmental series of Wt1 mutants. Disease Models & Mechanisms Vol: 8 Pages: 903-17. More»
  • Nils Lindstrom, Melanie L Lawrence, Sally F Burn, Jeanette A Johansson, Elvira Rm Bakker, Rachel A Ridgway, C-hong Chang, Michele J Karolak, Leif Oxburgh, Denis J Headon, Owen J Sansom, Ron Smits, Jamie A Davies, Peter Hohenstein. 2015. Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron. eLIFE Vol: 4. More»
  • Peter Hohenstein, K Pritchard-Jones, J Charlton. 2015. The Yin and Yang of kidney development and Wilms’ tumours. Genes & Development Vol: 29 Pages: 467-482. More»
  • Nils Lindstrom, Neil Carragher, Peter Hohenstein. 2015. The PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through beta-catenin signalling.. Stem Cell Reports Vol: 4 Pages: 551-560. More»
  • Kay-Dietrich Wagner, Julien Cherfils-Vicini, Naoki Hosen, Peter Hohenstein, Eric Gilson, Nicholas D Hastie, Jean-François Michiels, Nicole Wagner. 2014. The Wilms' tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression. Nature Communications Vol: 5 Pages: 5852. More»
  • Abdelkader Essafi, Anna Webb, Rachel L Berry, Joan Slight, Sally F Burn, Lee Spraggon, Victor Velecela, Ofelia M Martinez-Estrada, John H Wiltshire, Stefan G E Roberts, David Brownstein, Jamie A Davies, Nicholas D Hastie, Peter Hohenstein. 2011. A Wt1-Controlled Chromatin Switching Mechanism Underpins Tissue-Specific Wnt4 Activation and Repression. Developmental Cell Vol: 21 Pages: 559-574. More»