Dr Vicky MacRae

The Roslin Institute

Research Interests

Our group undertakes research in bone formation and vascular calcification. We examine the mechanisms of differentiation and calcification in growth plate chondrocytes, osteoblasts, vascular smooth muscle cells and valvular interstitial cells. Our research employs transgenic models and clinical samples and utilises use a range of molecular, histological and imaging techniques. The elucidation of new mechanisms of bone formation and vascular calcification may identify new potential therapeutic targets in human and animal disease.

Selected Publications

  • Dongxing Zhu, Neil C W Mackenzie, Jose Luis Millan, Colin Farquharson, Vicky E Macrae. 2013. A protective role for FGF-23 in local defence against disrupted arterial wall integrity?. Molecular and Cellular Endocrinology Vol: 372 Pages: 1-11. More»
  • Tina Kiffer-Moreira, Manisha C. Yadav, Dongxing Zhu, Sonoko Narisawa, Campbell Sheen, Boguslaw Stec, Nicholas D. Cosford, Russell Dahl, Colin Farquharson, Marc F. Hoylaerts, Vicky E. MacRae, Jose Luis Millan. 2013. Pharmacological Inhibition of PHOSPHO1 Suppresses Vascular Smooth Muscle Cell Calcification. Journal of Bone and Mineral Research Vol: 28 Pages: 81-91. More»
  • Vicky MacRae, S Horvat, S C Pells, H Dale, R S Collinson, A A Pitsillides, S F Ahmed, C Farquharson. 2009. Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice. Journal of Cellular Physiology Vol: 218 Pages: 276-84. More»
  • Neil Charles Wallace Mackenzie, Dongxing Zhu, Elspeth M Milne, Rob van 't Hof, Aline Martin, Darryl Leigh Quarles, José Luis Millán, Colin Farquharson, Vicky Elisabeth Macrae. 2012. Altered Bone Development and an Increase in FGF-23 Expression in Enpp1-/- Mice. PLoS One Vol: 7. More»
  • Dongxing Zhu, N. C. W. Mackenzie, J. L. Millan, C. Farquharson, V. E. MacRae. 2011. The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells. PLoS One Vol: 6. More»
  • Vicky MacRae, Megan Davey, Lynn McTeir, Sonoko Narisawa, Manisha C. Yadav, Jose Luis Millan, Colin Farquharson. 2010. Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick. Bone Vol: 46 Pages: 1146-55. More»